AcneStop -Azelaic acid

Pharmacodynamics
Azelaic acid, the active ingredient in AcneStop, is a naturally occurring straight-chain dicarboxylic acid that is non-toxic, non-teratogenic, and non-mutagenic.The therapeutic effectiveness of AcneStop in acne treatment is believed to be due to its antimicrobial action and direct impact on follicular hyperkeratosis.Clinically, it significantly reduces the density of Propionibacterium acnes colonization and decreases the fraction of free fatty acids in skin surface lipids.Azelaic acid inhibits keratinocyte proliferation, normalizes terminal differentiation disorders in acne formation, and accelerates comedolysis of tetradecan-induced comedones in rabbit ear models.At concentrations of 0.31–2.5%, azelaic acid exhibits a biocidal effect after prolonged contact (30–120 minutes) against Gram-positive and Gram-negative aerobic bacteria, anaerobic bacteria, and fungi.In vitro studies have shown no mutant strains resistant to azelaic acid in Staphylococcus epidermidis or Propionibacterium acnes.

Pharmacokinetics
After application, azelaic acid penetrates all layers of human skin, with faster absorption through affected skin compared to intact skin. 3.6% of the applied dose is systemically absorbed after a single 1g application (5g of cream).Part of the absorbed azelaic acid is excreted unchanged in urine, while the rest undergoes β-oxidation, breaking down into short-chain dicarboxylic acids (C7, C5), which are also excreted in urine.Studies on systemic tolerance of azelaic acid showed no adverse effects, even under extreme conditions (e.g., large-area application or occlusion).
IndicationsTreatment of acne vulgaris, characterized by comedones, papules, pustules, and small nodules.

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• Standard shipping: 3-5 business days.
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